{"id":3624,"date":"2022-06-24T08:47:51","date_gmt":"2022-06-24T06:47:51","guid":{"rendered":"https:\/\/cendoc.h12o.es\/blog\/?p=3624"},"modified":"2022-06-24T08:47:51","modified_gmt":"2022-06-24T06:47:51","slug":"variantes-geneticas-y-gravedad-de-covid-19","status":"publish","type":"post","link":"https:\/\/cendoc.h12o.es\/blog\/2022\/06\/24\/variantes-geneticas-y-gravedad-de-covid-19\/","title":{"rendered":"Variantes gen\u00e9ticas y gravedad de COVID-19"},"content":{"rendered":"<p>Esther Mancebo y Estela Paz Artal, del Servicio de Inmunolog\u00eda del Hospital 12 de Octubre, son dos de las autoras del art\u00edculo <img loading=\"lazy\" decoding=\"async\" class=\" wp-image-3871 alignright\" src=\"https:\/\/coronavirusbiblioh12o.files.wordpress.com\/2020\/05\/logo12.jpg?w=218&amp;h=148\" alt=\"logo12\" width=\"218\" height=\"148\" data-attachment-id=\"3871\" data-permalink=\"https:\/\/coronavirusbiblioh12o.wordpress.com\/2020\/05\/06\/7-mas-del-h12o\/logo12\/\" data-orig-file=\"https:\/\/coronavirusbiblioh12o.files.wordpress.com\/2020\/05\/logo12.jpg\" data-orig-size=\"275,183\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"logo12\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/coronavirusbiblioh12o.files.wordpress.com\/2020\/05\/logo12.jpg?w=275\" data-large-file=\"https:\/\/coronavirusbiblioh12o.files.wordpress.com\/2020\/05\/logo12.jpg?w=275\" \/>\u201c<a href=\"https:\/\/www.nature.com\/articles\/s41598-022-14035-x\">Presence of rare potential pathogenic variants in subjects under 65 years old with very severe or fatal COVID-19<\/a>\u201c publicado en <em>Scientific Reports<\/em>.<\/p>\n<p>Su objetivo es analizar la presencia de variantes gen\u00e9ticas raras en determinados genes en un grupo de pacientes con COVID-19 menores de 65 a\u00f1os que necesitaron intubaci\u00f3n o fallecieron. Se detectaron 44 variantes diferentes de inter\u00e9s en 29 pacientes diferentes (66%). Algunas de estas variantes se hab\u00edan descrito previamente como pat\u00f3genas y estaban localizadas en genes implicados de forma importante en la respuesta inmunitaria. Un an\u00e1lisis de redes, incluyendo los 42 genes con variantes candidatas, mostr\u00f3 tres componentes principales, consistentes en 25 genes altamente interconectados relacionados con la respuesta inmune y dos redes adicionales compuestas por genes enriquecidos en el metabolismo de los carbohidratos y en los procesos de metabolismo y reparaci\u00f3n del ADN.<\/p>\n<p>En conclusi\u00f3n, con los datos de este estudio se han detectado variantes candidatas que pueden influir potencialmente en el resultado de la COVID-19 en esta cohorte de pacientes. Se necesitar\u00edan m\u00e1s estudios para confirmar el papel definitivo de las variantes gen\u00e9ticas descritas en este art\u00edculo sobre la gravedad de la COVID-19.<\/p>\n<p><em>Equipo Biblioteca H12O<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Esther Mancebo y Estela Paz Artal, del Servicio de Inmunolog\u00eda del Hospital 12 de Octubre, son dos de las autoras del art\u00edculo \u201cPresence of rare potential pathogenic variants in subjects under 65 years old with very severe or fatal COVID-19\u201c publicado en Scientific Reports. Su objetivo es analizar la presencia \u2026<\/p>\n<p class=\"continue-reading-button\"> <a class=\"continue-reading-link\" href=\"https:\/\/cendoc.h12o.es\/blog\/2022\/06\/24\/variantes-geneticas-y-gravedad-de-covid-19\/\">Continuar leyendo<i class=\"crycon-right-dir\"><\/i><\/a><\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[4,64,46],"tags":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_shortlink":"https:\/\/wp.me\/p3G9TJ-Ws","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/cendoc.h12o.es\/blog\/wp-json\/wp\/v2\/posts\/3624"}],"collection":[{"href":"https:\/\/cendoc.h12o.es\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cendoc.h12o.es\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cendoc.h12o.es\/blog\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/cendoc.h12o.es\/blog\/wp-json\/wp\/v2\/comments?post=3624"}],"version-history":[{"count":1,"href":"https:\/\/cendoc.h12o.es\/blog\/wp-json\/wp\/v2\/posts\/3624\/revisions"}],"predecessor-version":[{"id":3625,"href":"https:\/\/cendoc.h12o.es\/blog\/wp-json\/wp\/v2\/posts\/3624\/revisions\/3625"}],"wp:attachment":[{"href":"https:\/\/cendoc.h12o.es\/blog\/wp-json\/wp\/v2\/media?parent=3624"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cendoc.h12o.es\/blog\/wp-json\/wp\/v2\/categories?post=3624"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cendoc.h12o.es\/blog\/wp-json\/wp\/v2\/tags?post=3624"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}